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BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19.
- Source :
- Vaccines; Apr2021, Vol. 9 Issue 4, p324, 1p
- Publication Year :
- 2021
-
Abstract
- BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge. [ABSTRACT FROM AUTHOR]
- Subjects :
- COVID-19
SARS-CoV-2
COVID-19 vaccines
TRANSGENIC mice
LUNG diseases
Subjects
Details
- Language :
- English
- ISSN :
- 2076393X
- Volume :
- 9
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Vaccines
- Publication Type :
- Academic Journal
- Accession number :
- 150435299
- Full Text :
- https://doi.org/10.3390/vaccines9040324