Association between dietary intake and risk of ovarian cancer: a systematic review and meta-analysis.

Purpose: It is unclear how dietary intake influences the ovarian cancer. The present paper sets out to systematically review and meta-analyze research on dietary intake to identify cases having high- or low-risk ovarian cancer. Methods: Scopus, PubMed, and Wiley Online Libraries were searched up to the date November 24, 2019. Two reviewers were requested to independently extract study characteristics and to assess the bias and applicability risks with reference to the study inclusion criteria. Meta-analyses were performed to specify the relationship between dietary intake and the risk of ovarian cancer identifying 97 cohort studies. Results: No significant association was found between dietary intake and risk of ovarian cancer. The results of subgroup analyses indicated that green leafy vegetables (RR = 0.91, 95%, 0.85–0.98), allium vegetables (RR = 0.79, 95% CI 0.64–0.96), fiber (RR = 0.89, 95% CI 0.81–0.98), flavonoids (RR = 0.83, 95% CI 0.78–0.89) and green tea (RR = 0.61, 95% CI 0.49–0.76) intake could significantly reduce ovarian cancer risk. Total fat (RR = 1.10, 95% CI 1.02–1.18), saturated fat (RR = 1.11, 95% CI 1.01–1.22), saturated fatty acid (RR = 1.19, 95% CI 1.04–1.36), cholesterol (RR = 1.13, 95% CI 1.04–1.22) and retinol (RR = 1.14, 95% CI 1.00–1.30) intake could significantly increase ovarian cancer risk. In addition, acrylamide, nitrate, water disinfectants and polychlorinated biphenyls were significantly associated with an increased risk of ovarian cancer. Conclusion: These results could support recommendations to green leafy vegetables, allium vegetables, fiber, flavonoids and green tea intake for ovarian cancer prevention. [ABSTRACT FROM AUTHOR]