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Diagnostic Performance of the Fujifilm SILVAMP TB-LAM in Children with Presumptive Tuberculosis.

Authors :
Comella-del-Barrio, Patricia
Molina-Moya, Bárbara
Gautier, Jacqueline
Villar-Hernández, Raquel
Doresca, Mariette Jean Coute
Sallés-Mingels, Beatriz
Canales-Aliaga, Lydia
Narcisse, Margareth
Pérez-Porcuna, Tomás M.
Creswell, Jacob
Cuevas, Luis E.
Domínguez, José
Garcia-Marcos, Luis
Source :
Journal of Clinical Medicine; May2021, Vol. 10 Issue 9, p1914-1914, 1p
Publication Year :
2021

Abstract

Current diagnostics for tuberculosis (TB) only manage to confirm a small proportion of children with TB and require respiratory samples, which are difficult to obtain. There is a need for non-invasive biomarker-based tests as an alternative to sputum testing. Fujifilm SILVAMP TB lipoarabinomannan (FujiLAM), a lateral-flow test to detect lipoarabinomannan in urine, is a novel non-sputum-based point-of-care diagnostic reported to have increased sensitivity for the diagnosis of TB among human immunodeficiency virus (HIV)-infected adults. We evaluate the performance of FujiLAM in children with presumptive TB. Fifty-nine children attending a paediatric hospital in Haiti with compatible signs and symptoms of TB were examined using Xpert MTB/RIF, smear microscopy and X-rays, and classified according to the certainty of diagnosis into bacteriologically confirmed TB (n = 5), unconfirmed TB (bacteriologically negative, n = 50) and unlikely TB (n = 4). Healthy children (n = 20) were enrolled as controls. FujiLAM sensitivity and specificity were 60% and 95% among children with confirmed TB. FujiLAM's high specificity and its characteristics as a point-of-care indicate the test has a good potential for the diagnosis of TB in children. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20770383
Volume :
10
Issue :
9
Database :
Complementary Index
Journal :
Journal of Clinical Medicine
Publication Type :
Academic Journal
Accession number :
150375539
Full Text :
https://doi.org/10.3390/jcm10091914