Circular RNA profiling distinguishes medulloblastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma.

1 Circular RNA expression profiles define medulloblastoma groups. a Circular RNA (circRNA) signal across fetal brain controls (healthy, n = 12), discovery (n = 38) and validation medulloblastoma (MB) cohort (n = 35). b, c Heatmap of top 500 differentially expressed circRNAs in discovery (b) and in validation data set (c), hierarchical clustering by average Pearson dissimilarity, circRNA MB groups: WNT blue, SHH red, G3 yellow, G4 green. d Circular RNA signals across discovery data set similarity network fusion (SNF) MB groups. e Circular RNA signal across discovery data set (circRNA MB groups). f Circular RNA signal across validation data set (circRNA MB groups). g Medulloblastoma grouping according to [[3]] and circRNA data in discovery data set. To discern group-specific and subtype-specific circRNA biomarkers, we performed differential expression analysis of the circRNA-defined groups (Fig. Circular RNAs (circRNA) recently emerged as promising biomarkers with cell type- and developmental stage-specific expression patterns in human tissues and cancers [[10]]. [Extracted from the article]