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Sarcopenia and Visceral Metastasis at Cabazitaxel Initiation Predict Prognosis in Patients With Castration-resistant Prostate Cancer Receiving Cabazitaxel Chemotherapy.
- Source :
- In Vivo; May/Jun2021, Vol. 35 Issue 3, p1703-1709, 7p
- Publication Year :
- 2021
-
Abstract
- Background/Aim: Cabazitaxel is recommended as first-line treatment after docetaxel for metastatic castration-resistant prostate cancer. However, the efficacy, adverse events and prognostic factors associated with cabazitaxel are unclear. Patients and Methods: This single-centre retrospective study including 30 patients with CRPC treated with cabazitaxel between 2014 and 2020 investigated efficacy, outcomes and prognostic factors. Results: Fourteen patients had visceral metastases. The median cabazitaxel dose was 20 mg/m². The prostate-specific antigen response rate, time to prostate-specific antigen response, and overall survival were 13.3%, 3.48 months, and 7.92 months, respectively. The rates of grade 3 or more neutropenia and febrile neutropenia were 20% and 6.7%, respectively. By multivariate analysis, sarcopenia and visceral metastasis at the time of cabazitaxel initiation were independent and significant factors conferring a poor prognosis. Conclusion: The early introduction of cabazitaxel, prior to the development of sarcopenia and visceral metastasis, might contribute to improved prognosis in CRPC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0258851X
- Volume :
- 35
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- In Vivo
- Publication Type :
- Academic Journal
- Accession number :
- 150111580
- Full Text :
- https://doi.org/10.21873/invivo.12430