MELATONIN AMELIORATES LIPID PEROXIDATION AND STATUS OF ANTIOXIDANT ENZYMES ALONG WITH EXPRESSION OF RORα IN LUNGS OF STREPTOZOTOCIN INDUCED DIABETIC ALBINO RAT.

Hyperglycemia leads to a state of amplified free radical production. The aim of our present study was to note the effect of melatonin on oxidative stress in lung of diabetic albino rats. We checked the oxidative stress of lung tissue by noting down the variation in lipid peroxidation in terms of malondialdehyde level and status of antioxidant enzymes (superoxide dismutase and catalase) along with expression of RORαunder different treatment conditions. Streptozotocin treatment increased lipid peroxidation and upregulated expression of RORα and decreased enzyme activity. Melatonin treatment decreased lipid peroxidation and increased the activity of antioxidant enzymes as well as downregulated the expression of RORα. These findings suggest that melatonin might be acting as a potential antioxidant in lung during diabetic condition. Variation in the expression of RORα also shows that melatonin might be acting through this nuclear recptor. [ABSTRACT FROM AUTHOR]