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Oligonucleotide-Based Approaches to Inhibit Dengue Virus Replication.
- Source :
- Molecules; Feb2021, Vol. 26 Issue 4, p956-956, 1p
- Publication Year :
- 2021
-
Abstract
- Dengue fever is one of the most common viral infections affecting humans. It is an expanding public health problem, particularly in tropical and subtropical regions. No effective vaccine or antiviral therapies against Dengue virus (DENV) infection are available. Therefore, there is a strong need to develop safe and effective therapeutic strategies that can reduce the burden and duration of hospitalizations due to this life-threatening disease. Oligonucleotide-based strategies are considered as an attractive means of inhibiting viral replication since oligonucleotides can be designed to interact with any viral RNA, provided its sequence is known. The resultant targeted destruction of viral RNA interferes with viral replication without inducing any adverse effects on cellular processes. In this review, we elaborate the ribozymes, RNA interference, CRISPR, aptamer and morpholino strategies for the inhibition of DENV replication and discuss the challenges involved in utilizing such approaches. [ABSTRACT FROM AUTHOR]
- Subjects :
- DENGUE viruses
VIRAL replication
DENGUE
CATALYTIC RNA
VIRUS diseases
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 149852222
- Full Text :
- https://doi.org/10.3390/molecules26040956