High diagnostic yield of splenic core biopsy in patients with pyrexia of unknown origin.

Keywords: Spleen; Biopsy; Pyrexia of unknown origin; FDG PET-CT; Diagnostic yield EN Spleen Biopsy Pyrexia of unknown origin FDG PET-CT Diagnostic yield e15 e18 4 04/19/21 20210415 NES 210415 A proportion of patients with pyrexia of unknown origin (PUO), or inflammation of unknown origin (IUO), are without a diagnosis following extensive clinical and laboratory evaluation.1-3 The outcome in this group of patients is variable; those with significant systemic inflammation may have prolonged hospital stays and a high mortality rate. Despite these limitations, the present study demonstrates the utility of image-guided splenic core biopsy in people with an inflammatory or infectious presentation and splenic imaging abnormalities who do not have a diagnosis despite extensive investigation. 2018; 48: 100 - 7. 8 Patel N, Dawe G, Tung K. Ultrasound-guided percutaneous splenic biopsy using an 18-G core biopsy needle: our experience with 52 cases. Of the other three patients, one was diagnosed by bone marrow aspirate and trephine biopsy (BMAT) one had no diagnosis on BMAT as well and one was diagnosed by liver biopsy I TableComparing histopathology of splenic biopsy with the final diagnosis. [Extracted from the article]