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Role of B-cells in Mycosis Fungoides.
- Source :
- Acta Dermato-Venereologica; Mar2021, Vol. 101 Issue 3, p1-7, 7p
- Publication Year :
- 2021
-
Abstract
- Mycosis fungoides is the most common type of cutaneous T-cell lymphoma. The inflammatory microenvironment in mycosis fungoides is complex. There is accumulating evidence that the neoplastic T-cells take control of the microenvironment and thereby promote their own expansion by suppressing cellular immunity. B-cells have proved to be upregulated in large-cell transformed mycosis fungoides, and could potentially play a role in disease progression. To investigate the presence of B-cells in mycosis fungoides compared with controls, this study analysed 85 formalin-fixed and paraffin-embedded mycosis fungoides biopsies. MS4A1 gene expression was significantly upregulated in mycosis fungoides compared with controls (p < 0.0001) and further upregulated in disease progression, (p = 0.001). Digital quantification of PAX5+/CD20+ cells confirmed the increased presence of Bcells in mycosis fungoides compared with controls. No co-labelling of CD3/CD20 was observed in the neoplastic T-cells. This study found a significantly increased presence of B-cells in the tumour-associated microenvironment in mycosis fungoides. These findings could potentially lead to new treatment strategies for mycosis fungoides. [ABSTRACT FROM AUTHOR]
- Subjects :
- MYCOSIS fungoides
CUTANEOUS T-cell lymphoma
B cells
CELLULAR immunity
Subjects
Details
- Language :
- English
- ISSN :
- 00015555
- Volume :
- 101
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Acta Dermato-Venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 149768823
- Full Text :
- https://doi.org/10.2340/00015555-3775