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Identification of SHMT2 as a Potential Prognostic Biomarker and Correlating with Immune Infiltrates in Lung Adenocarcinoma.

Authors :
Luo, Lianxiang
Zheng, Yushi
Lin, Zhiping
Li, Xiaodi
Li, Xiaoling
Li, Mingyue
Cui, Liao
Luo, Hui
Source :
Journal of Immunology Research; 4/8/2021, p1-18, 18p, 1 Black and White Photograph, 3 Diagrams, 7 Graphs
Publication Year :
2021

Abstract

It has attracted growing attention that the role of serine hydroxy methyl transferase 2 (SHMT2) in various types of cancers. However, the prognostic role of SHMT2 in lung adenocarcinoma (LUAD) and its relationship with immune cell infiltration is not clear. In this study, the information of mRNA expression and clinic data in LUAD were, respectively, downloaded from the GEO and TCGA database. We conducted a biological analysis to select the signature gene SHMT2. Online databases including Oncomine, GEPIA, TISIDB, TIMER, and HPA were applied to analyze the characterization of SHMT2 expression, prognosis, and the correlation with immune infiltration in LUAD. The mRNA expression and protein expression of SHMT2 in LUAD tissues were higher than in normal tissue. A Kaplan-Meier analysis showed that patients with lower expression level of SHMT2 had a better overall survival rate. Multivariate analysis and the Cox proportional hazard regression model revealed that SHMT2 expression was an independent prognostic factor in patients with LUAD. Meanwhile, the gene SHMT2 was highly associated with tumor-infiltrating lymphocytes in LUAD. These results suggest that the SHMT2 gene is a promising candidate as a potential prognostic biomarker and highly associated with different types of immune cell infiltration in LUAD. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23148861
Database :
Complementary Index
Journal :
Journal of Immunology Research
Publication Type :
Academic Journal
Accession number :
149710700
Full Text :
https://doi.org/10.1155/2021/6647122