Keeping pain away by distancing the plasma membrane from the endoplasmic reticulum.

The decrease in ER Ca SP 2+ sp is sensed by STIM1 proteins, which aggregate and move closer to the plasma membrane, and activate Orai1 channels by protein-protein interaction (Woo I et al i . 2018) (Fig. The resulting decrease in ER Ca2+ content is sensed by the Ca2+ binding protein STIM1, which activates plasma Orai1 channels in the plasma membrane by protein-protein interaction. [Extracted from the article]