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Rhodium‐Catalyzed Atroposelective Construction of Indoles via C−H Bond Activation.
- Source :
- Angewandte Chemie; 4/6/2021, Vol. 133 Issue 15, p8472-8476, 5p
- Publication Year :
- 2021
-
Abstract
- Reported herein is the rhodium(III)‐catalyzed C−H activation of anilines bearing an N‐isoquinolyl directing group for oxidative [3+2] annulation with four classes of internal alkynes, leading to atroposelective indole synthesis via dynamic kinetic annulation with C‐N reductive elimination constituting the stereo‐determining step. This reaction proceeds under mild conditions with high regio‐ and enantioselectivity and functional group compatibility. [ABSTRACT FROM AUTHOR]
- Subjects :
- INDOLE compounds
RHODIUM
ANNULATION
CHIRALITY element
INDOLE
FUNCTIONAL groups
Subjects
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 133
- Issue :
- 15
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 149552077
- Full Text :
- https://doi.org/10.1002/ange.202012932