Correspondence.

The article focuses on the role of sweat in the pharmacokinetics of ketoconazole and griseofulvin. Griseofulvin and ketoconazole have been shown to be quickly transfered by sweat to the surface of healthy skin. This effect in normal skin is very important in treatment with both griseofulvin and ketoconazole. There is possibility of indirect transfer of these drugs to fungal lesions by sweat from, for instance, adjacent normal skin and contact with apposing skin surfaces and clothes.