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NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling.

Authors :
Britton, Heidi M.
Levine, Adrian B.
Shen, Yaoqing
Mungall, Karen
Serrano, Jonathan
Snuderl, Matija
Pleasance, Erin
Jones, Steven J. M.
Laskin, Janessa
Marra, Marco A.
Rassekh, Shahrad R.
Deyell, Rebecca
Yip, Stephen
Cheng, Sylvia
Dunham, Chris
Source :
Clinical Case Reports; Mar2021, Vol. 9 Issue 3, p1472-1477, 6p
Publication Year :
2021

Abstract

This is the first report of a NACC2‐NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been identified through routine diagnostics, demonstrating the value of clinical genome profiling in cancer care. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20500904
Volume :
9
Issue :
3
Database :
Complementary Index
Journal :
Clinical Case Reports
Publication Type :
Academic Journal
Accession number :
149399594
Full Text :
https://doi.org/10.1002/ccr3.3804