"Response to the letter to the editor "Concerns regarding the potentially causal role of FANCA heterozygous variants in human primary ovarian insufficiency"".

We encourage centers with large cohorts of POI patients as well as FA patients to precisely define the genotype-phenotype correlations in women with I FANC i variants. To the Editor, We thank Heddar and Misrahi for their interest in our recent paper (Yang et al. [20]), and for sharing their different opinions on the causal link between I FANCA i variants and premature ovarian insufficiency (POI). First, no rare variant in any other causative/candidate POI genes has been found in our I FANCA i -associated patients after processing whole-exome sequencing (WES) data. [Extracted from the article]