Acute generalized exanthematous pustulosis induced by enoxaparin: 2 cases.

Keywords: AGEP; case report; cross-allergy; heparins; intradermal test EN AGEP case report cross-allergy heparins intradermal test 280 282 3 03/22/21 20210401 NES 210401 Delayed-type hypersensitivity skin reactions to heparins are frequent (7.5% of patients treated), occurring mainly as eczematous lesions at injection sites and, very rarely, as severe cutaneous adverse reactions.1 We report two cases of enoxaparin-induced acute generalized exanthematous pustulosis (AGEP) and discuss cross-reactivity between heparins. AGEP, case report, cross-allergy, heparins, intradermal test Patient 1 reported a similar previous diffuse desquamative rash occurring 13 years earlier after surgery, in which heparin administration was probable, and patient 2, a rash occurring 3 years earlier, when enoxaparin was among the culprit drugs, but had not been tested at the time. [Extracted from the article]