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Efficacy of Aloe-Vera Use for Prevention of Chemotherapy-Induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia: A Randomized Controlled Clinical Trial.
- Source :
- Comprehensive Child & Adolescent Nursing; Mar2021, Vol. 44 Issue 1, p49-62, 14p, 1 Color Photograph, 1 Diagram, 3 Charts, 1 Graph
- Publication Year :
- 2021
-
Abstract
- Oral mucositis can be caused by chemotherapy and can affect a patient's quality of life. Nowadays, to prevent chemotherapy-induced oral mucositis (CIOM) is a crucial point in palliative care centers. This trial aimed to assess the effectiveness of aloe-vera in that concept. The trial was accomplished at Hematology Department of Hospital of Children of Damascus University, Syria. Acute lymphoblastic leukemia (ALL) children were the population from which 26 children were enrolled in the study. They were aged between 3 and 6 years old and were randomly referred according to the intervention into two groups, Aloe-vera (AV) and sodium bicarbonate 5% (13 each). Spongeous sticks were used to help in applying the material on tongue, labial and buccal mucosa, lips, floor of the mouth, and hard palate. Two blinded external examiners evaluated oral mucosa weekly for up to 2 months using the World Health Organization grading scale. Mann–Whitney U test was used to analyze data. According to the observed findings, CIOM degrees were less severe in the aloe-vera group than in the sodium bicarbonate group. Statistically significant difference of occurrence of different CIOM degrees between groups was recorded in the 2nd, 3rd, 4th, and 7th weeks of follow-up period. Moreover, Mann–Whitney U test indicated that patients in the sodium bicarbonate group began CIOM sooner than those in the aloe-vera group with a statistically significant difference (p =.001). These findings show that topical application of aloe-vera solution is effective in the prevention of CIOM in ALL children. [ABSTRACT FROM AUTHOR]
- Subjects :
- DRUG efficacy
SODIUM bicarbonate
STOMATITIS
ACADEMIC medical centers
SAMPLE size (Statistics)
LYMPHOBLASTIC leukemia
CANCER chemotherapy
CHILDREN'S hospitals
ANTINEOPLASTIC agents
MANN Whitney U Test
RANDOMIZED controlled trials
CANCER patients
COMPARATIVE studies
ALOE
DESCRIPTIVE statistics
SOLUTION (Chemistry)
CUTANEOUS therapeutics
STATISTICAL sampling
ORAL mucosa
DATA analysis software
LONGITUDINAL method
EVALUATION
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 24694193
- Volume :
- 44
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Comprehensive Child & Adolescent Nursing
- Publication Type :
- Academic Journal
- Accession number :
- 149334317
- Full Text :
- https://doi.org/10.1080/24694193.2020.1727065