Lichen planus pemphigoides-like lesions induced by cinnarizine.

A 72-year-old woman developed a lichen planus pemphigoides-like eruption following the administration of cinnarizine. The eruption recurred on challenge with the drug. Direct immunofluorescence studies of the lesions demonstrated deposition of IgG, IgM and C₃ on colloid bodies and fibrin at the epidermal basement membrane zone. Circulating IgG antibasement membrane zone antibodies were detected at high titres, with no complement-fixing activities. To our knowledge, this is the first report of immunologically defined lichen planus pemphigoides induced by a drug. [ABSTRACT FROM AUTHOR]