Association of NOS3-c.894G>T transversion with susceptibility to metabolic syndrome in Azar-cohort population: A case-control study and in silico analysis of the SNP molecular effects.

However, the eNOS-298D variant had slightly changed RMSD when it submitted as a ligand in eNOS-298E/ eNOS-298D (RMSD=0.29) or eNOS-298D/eNOS-298D dimer (RMSD=0.31). STRING identified 11 eNOS-interacting proteins, among which literature search showed, four proteins CAV1 (37), HSP90AA1 (38), CALM1 (39), and NOSTRIN (40) bound to eNOS through its oxygenase domain. Also, RMSD (Root mean square deviation) of eNOS-298E variant in both eNOS-298E/eNOS-298E and eNOS-298D/eNOS-298E dimers was the same (0.32). However, by reviewing the literature it is concluded that among STRING-reported functional partners of eNOS, CAV1 (37), HSP90AA1 (38), CALM1 (39), and NOSTRIN (40) interact directly with the eNOS oxygenase domain Docking Docking energy score Ligand RMSD (Å) Receptor Ligand eNOS-298E eNOS-298E-1036.83 0.32 eNOS-298E eNOS-298D-968.28 0.29 eNOS-298D eNOS-298E-1012.05 0.32 eNOS-298D eNOS-298D-1037.89 0.31 Figure 8. [Extracted from the article]