Back to Search
Start Over
Connected speech in progressive supranuclear palsy: a possible role in differential diagnosis.
- Source :
- Neurological Sciences; Apr2021, Vol. 42 Issue 4, p1483-1490, 8p, 6 Charts
- Publication Year :
- 2021
-
Abstract
- Background: Progressive supranuclear palsy (PSP) is an atypical Parkinsonism characterized by motor and neuropsycological disorders. Language could be impaired in PSP patients, also in Richardson variant (PSP-RS). The analysis of connected speech is used in neurodegenerative disorder to investigate different levels of language organization, including phonetic, phonological, lexico-semantic, morpho-syntactic, and pragmatic processing. Objective: In our study, we aimed to investigate the language profile, especially connected speech, in early-stage PSP-RS and Parkinson's disease (PD) patients without predominant speech or language disorders. Methods: Language was assessed using the Screening for Aphasia in NeuroDegeneration (SAND); connected speech analysis was conducted from the picture description subtest. Results: We enrolled 48 patients, 22 PD and 26 PSP (18 PSP-RS and 8 non-RS). PSP-RS patients presented an impairment in language domain, particularly regarding connected speech. PSP-RS patients presented worse performances than PD in different scores. The output of PSP-RS patients was characterized by a reduction in number of sentences and subordinates with respect to PD; PSP presented also more repaired sequences and phonological and lexico-semantic errors than PD. Number of sentences and number of subordinates of the picture description task were identified as predictors of PSP diagnosis. Conclusion: In summary, the SAND scale is able to identify language impairment in PSP patients. The analysis of connected speech could highlight some important aspects of language impairment in PSP-RS patients, and it could be helpful in the differential diagnosis with PD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15901874
- Volume :
- 42
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Neurological Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 149268413
- Full Text :
- https://doi.org/10.1007/s10072-020-04635-8