Dexmedetomidine and Tear Production: Evaluation in Dogs as Spontaneous Model for Ocular Surface Disorders.

The general anesthesia or sedation reduces both the tear production and the stability of tear film that protect corneal surface, predisposing itself to the exposure keratopathy. The aim of the present study was to evaluate the effects of intramuscular dexmedetomidine (DEX) on canine tear production, measured by standardized Schirmer Tear Test 1 (STT-1) strips, for the 8 h following sedation, in dogs. A significant effect of time on canine tear production was found, highlighting that dexmedetomidine sedative protocol significantly affects tear production in dogs. It is recommended to treat the canine eyes with tear substitutes to protect ocular surface health and the welfare of the dogs. The ocular lubrication should be performed during and up to 12 h after sedation. The present report could provide preliminary information to better understand the effect of DEX on the tear film dynamics. Tear film provides lubrication and protection to the ocular surface. The sedation reduces tear production, often leading to perioperative exposure keratopathy. The aim of the present study was to report the effects of intramuscular dexmedetomidine on canine tear production, measured by STT-1, for an experimental period of 8 h after sedation. Ten dogs who underwent sedation for routine radiologic assessment were recruited for the study. In all animals, tear production in right and left eyes was measured 15 min before sedation (T0: basal values) and 20 min (T20), 1 h (T1), 2 h (T2), 4 h (T4) and 8 h (T8) after drug administration. Analysis of variance and post hoc Bonferroni test (p < 0.05) were performed. A significant effect of time on canine tear production was found. The tear production returned to basal values at T8. So, it is recommended to treat the canine eyes with tear substitutes during and up to 12 h after sedation. [ABSTRACT FROM AUTHOR]