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A synthetic peptide rescues rat cortical neurons from anesthetic-induced cell death, perturbation of growth and synaptic assembly.

Authors :
Iqbal, Fahad
Pehar, Marcus
Thompson, Andrew J.
Azeem, Urva
Jahanbakhsh, Kiana
Jimenez-Tellez, Nerea
Sabouny, Rasha
Batool, Shadab
Syeda, Atika
Chow, Jennifer
Machiraju, Pranav
Shutt, Timothy
Yusuf, Kamran
Shearer, Jane
Rice, Tiffany
Syed, Naweed I.
Source :
Scientific Reports; 2/25/2021, Vol. 11 Issue 1, p1-17, 17p
Publication Year :
2021

Abstract

Anesthetics are deemed necessary for all major surgical procedures. However, they have also been found to exert neurotoxic effects when tested on various experimental models, but the underlying mechanisms remain unknown. Earlier studies have implicated mitochondrial fragmentation as a potential target of anesthetic-induced toxicity, although clinical strategies to protect their structure and function remain sparse. Here, we sought to determine if preserving mitochondrial networks with a non-toxic, short-life synthetic peptideā€”P110, would protect cortical neurons against both inhalational and intravenous anesthetic-induced neurotoxicity. This study provides the first direct and comparative account of three key anesthetics (desflurane, propofol, and ketamine) when used under identical conditions, and demonstrates their impact on neonatal, rat cortical neuronal viability, neurite outgrowth and synaptic assembly. Furthermore, we discovered that inhibiting Fis1-mediated mitochondrial fission reverses anesthetic-induced aberrations in an agent-specific manner. This study underscores the importance of designing mitigation strategies invoking mitochondria-mediated protection from anesthetic-induced toxicity in both animals and humans. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20452322
Volume :
11
Issue :
1
Database :
Complementary Index
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
149026509
Full Text :
https://doi.org/10.1038/s41598-021-84168-y