Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs.

Extensive hierarchical yet highly reciprocal interactions among cortical areas are fundamental for information processing. However, connectivity rules governing the specificity of such corticocortical connections, and top-down feedback projections in particular, are poorly understood. We analyze synaptic strength from functionally relevant brain areas to diverse neuronal types in the primary somatosensory cortex (S1). Long-range projections from different areas preferentially engage specific sets of GABAergic neurons in S1. Projections from other somatosensory cortices strongly recruit parvalbumin (PV)-positive GABAergic neurons and lead to PV neuron-mediated feedforward inhibition of pyramidal neurons in S1. In contrast, inputs from whisker-related primary motor cortex are biased to vasoactive intestinal peptide (VIP)-positive GABAergic neurons and potentially result in VIP neuron-mediated disinhibition. Regardless of the input areas, somatostatin-positive neurons receive relatively weak long-range inputs. Computational analyses suggest that a characteristic combination of synaptic inputs to different GABAergic IN types in S1 represents a specific long-range input area. • Diverse long-range inputs engage distinct GABAergic neurons in S1 • S2 inputs recruit PV neurons leading to feedforward inhibition of pyramidal cells in S1 • M1 inputs recruit VIP neurons leading to disinhibition of pyramidal cells in S1 • SST neurons receive relatively weak long-range inputs regardless of input area Naskar et al. show how functionally relevant brain areas interact with neurons in the primary somatosensory cortex, demonstrating that long-range projections from diverse brain areas differentially recruit specific subtypes of GABAergic neurons in S1, and each distinct subtype of GABAergic neurons differentially affects local network activity in S1. [ABSTRACT FROM AUTHOR]