6-[2-Phosphonomethoxy)Alkoxy]-2,4-Diaminopyrimidines: A New Class of Acyclic Pyrimidine Nucleoside Phosphonates with Antiviral Activity.

Acyclic nucleoside phosphonate derivatives containing a pyrimidine base preferably bearing amino groups at C-2 and C-4(DAPym), and linked at the C-6 position to(S)-[3-hydroxy-2-(phosphonomethoxy)propoxy](HPMPO), 2-(phosphonomethoxy) ethoxy(PMEO) or(R)-[2-(phosphonomethoxy)propoxy](PMPO), display an antiviral sensitivity spectrum that closely mimic that of the parental(S)-HPMP-, PME- and(R)-PMP-purine derivatives. Several PMEO-DAPym derivatives proved as potent as PMEA(adefovir) and(R)-PMPA(tenofovir) in inhibiting Moloney murine sarcoma virus(MSV)-induced tumor formation in newborn NMRI mice. The HPMPO-, PMEO- and PMPO-DAPym derivatives represent a novel well-defined subclass among the acyclic nucleoside phosphonates endowed with potent and selective antiviral activity. [ABSTRACT FROM AUTHOR]