Dysregulation of Phosphoinositide 5-Phosphatases and Phosphoinositides in Alzheimer's Disease.

PI 5-Phosphatases, PIs and AD FIGURE1 | The figure shows the schematic illustrations of the major domains of PI 5-phosphatases and summarizes the implications of PI 5-phosphatases and PIs in AD. Itremainstobecarefullydetermined in post-mortem brain tissues of AD patients whether there are changes in SHIP2 subcellular localizations, post-translational modifications and the impact of SHIP2 upregulation in AD on PIamounts,particularlyPI(3,4,5)P3andPI(3,4)P2. PIMetabolismand Autophagic-Endosomal-Lysosomal Abnormalities Consistent with alterations of some PI 5-phosphatases observed in AD brains, there are substantial findings suggesting that PIs undergo dysregulation during the disease progression in AD brains(StokesandHawthorne,1987)andintheADbloodplasma (Mapstone et al., 2014). OPINION published: 25 February 2021 doi: 10.3389/fnins.2021.614855 Frontiers in Neuroscience | www.frontiersin.org 1 February 2021 | Volume 15 | Article 614855 Edited by: Kin Ying Mok, University College London, United Kingdom Reviewedby: Tamas Balla, National Institutes of Health (NIH), United States *Correspondence: Kunie Ando Kunie.Ando@ulb.ac.be † These authors have contributed equally to this work Specialty section: This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience Received: 07 October 2020 Accepted: 26 January 2021 Published: 25 February 2021 Citation: Ando K, Erneux C, Homa M, Houben S, de Fisenne M-A, Brion J-P and Leroy K (2021) Dysregulation of Phosphoinositide 5-Phosphatases and Phosphoinositides in Alzheimer's Disease. [Extracted from the article]