Back to Search
Start Over
Self-Reported Symptoms of COVID-19, Including Symptoms Most Predictive of SARS-CoV-2 Infection, Are Heritable.
- Source :
- Twin Research & Human Genetics; Dec2020, Vol. 23 Issue 6, p316-321, 6p
- Publication Year :
- 2020
-
Abstract
- Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n = 3261) completing the C-19 COVID-19 symptom tracker app allowed classical twin studies of COVID-19 symptoms, including predicted COVID-19, a symptom-based algorithm to predict true infection, derived from app users tested for SARS-CoV-2. We found heritability of 49% (32-64%) for delirium; 34% (20-47%) for diarrhea; 31% (8-52%) for fatigue; 19% (0-38%) for anosmia; 46% (31-60%) for skipped meals and 31% (11-48%) for predicted COVID-19. Heritability estimates were not affected by cohabiting or by social deprivation. The results suggest the importance of host genetics in the risk of clinical manifestations of COVID-19 and provide grounds for planning genome-wide association studies to establish specific genes involved in viral infectivity and the host immune response. [ABSTRACT FROM AUTHOR]
- Subjects :
- COVID-19 pandemic
TWINS
HERITABILITY
ANOSMIA
GENOTYPES
Subjects
Details
- Language :
- English
- ISSN :
- 18324274
- Volume :
- 23
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Twin Research & Human Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 148886922
- Full Text :
- https://doi.org/10.1017/thg.2020.85