Personalized Dosing = Approved Wide Dose Ranges + Dose Titration.

I read with interest the excellent paper by Powell I et al i .1 entitled "Drug Dosing Recommendations for All Patients: A Roadmap for Change", wherein they discuss "adjusting drug development and regulation to enable effective dosing for all." If drug developers studied wide dose ranges throughout drug development, and regulators subsequently approved wide dose ranges, we would have a pragmatic framework for delivering personalized dosing based on dose titration for each patient. Personalized Dosing = Approved Wide Dose Ranges + Dose Titration. [Extracted from the article]