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PEGylated single-walled carbon nanotubes as co-adjuvants enhance expression of maturation markers in monocyte-derived dendritic cells.
- Source :
- Nanomedicine; Jan2021, Vol. 16 Issue 3, p171-188, 18p
- Publication Year :
- 2021
-
Abstract
- Aim: This study investigated the application of phospholipid-PEGylated single-walled carbon nanotubes (PL-PEG-SWCNTs) as a safe co-adjuvant for the commercial recombinant hepatitis B virus vaccine to enhance induction of monocyte-derived dendritic cells (MDDCs) differentiation and activation in vitro as an immune response initiator cell to prompt a long-term immune response after a single dose injection. Methods: Immature MDDCs were exposed to PL-PEG-SWCNTs alone and in combination with hepatitis B vaccine. Results & conclusion: Study results confirm the enhanced expression of maturation markers in human immature MDDCs after PL-PEG-SWCNT exposure. The results suggest that PL-PEG-SWCNT is an efficient co-adjuvant for the commercial recombinant hepatitis B virus vaccine to enhance dendritic cell response stimulation in vitro. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17435889
- Volume :
- 16
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 148748892
- Full Text :
- https://doi.org/10.2217/nnm-2020-0339