Clinical, inflammatory and microbiological outcomes of full‐mouth scaling with adjunctive glycine powder air‐polishing: A randomized trial.

Aim: To determine the effects of glycine powder air‐polishing (GPAP) as an adjunct to full‐mouth scaling and root planing (SRP) on clinical, inflammatory and microbiological outcomes in patients with untreated periodontitis. Materials and Methods: Forty‐one patients were randomly assigned to the control group A (SRP) and test groups B1 (subgingival GPAP right after SRP) and B2 (subgingival GPAP right before SRP). Clinical examinations and sample collections (saliva, subgingival plaque, serum and gingival crevicular fluid) were performed at assessment visits and before therapies at clinical visits of baseline, 6‐week and 3‐month. C‐reactive protein, IL‐6 and TNF‐α were assessed in serum and gingival crevicular fluid, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum were measured in saliva and subgingival plaque. Results: Patients in control and test groups did not significantly differ by age, sex and disease severity at baseline. Participants in control and intervention groups had similar improvements in clinical parameters (PD, BOP, PLI and BI). All groups had a similar percentage of sites showing PD reduction of ≥2 mm between baseline and follow‐up visits, with a few exceptions. Reduced C‐reactive protein, IL‐6 and TNF‐α in serum were found after treatments. Conclusion: Full‐mouth SRP with and without GPAP resulted in largely similar clinical, inflammatory and microbiological outcomes in the care of untreated periodontitis. [ABSTRACT FROM AUTHOR]