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An alarm system of carbamazepine‐induced toxic effects highly associated with HLA‐B*1502 allele.
- Source :
- Kaohsiung Journal of Medical Sciences; Feb2021, Vol. 37 Issue 2, p156-157, 2p
- Publication Year :
- 2021
-
Abstract
- An alarm system of carbamazepine-induced toxic effects highly associated with HLA-B*1502 allele Carbamazepine is widely used in epilepsy, trigeminal neuralgia, and bipolar disorder, but if it causes severe cutaneous adverse reactions including Steven-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN), and the mortality rate is as high as 30%.1 Because of the death of patient taking carbamazepine due to this serious adverse drug reaction in our hospital, we read the article "Carbamazepine-induced Toxic Effects and HLA-B1502* Screening in Taiwan" by Chen et al, and learned that this toxic reaction was strongly correlated with the HLA-B*1502 allele, and compared with other ethnic groups, this genotype is the highest proportion in Asian population.2 Therefore, this article recommended that Asian patients should undergo HLA-B*1502 genetic screening before taking carbamazepine to avoid serious adverse drug reactions caused by this drug. Therefore, we, located in Southeast Asia-Taiwan, are motivated to get actively involved in building a computer-based alarm system for carbamazepine and HLA-B*1502 allele cross matching. [Extracted from the article]
- Subjects :
- DRUG side effects
ALLELES
Subjects
Details
- Language :
- English
- ISSN :
- 1607551X
- Volume :
- 37
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Kaohsiung Journal of Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 148723472
- Full Text :
- https://doi.org/10.1002/kjm2.12324