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Role of nitric oxide signaling in the antidepressant mechanism of action of ketamine: A randomized controlled trial.
- Source :
- Journal of Psychopharmacology; Feb2021, Vol. 35 Issue 2, p124-127, 4p
- Publication Year :
- 2021
-
Abstract
- Ketamine is an N-methyl-D-aspartate receptor antagonist with rapid antidepressant effects. Studies suggest that inhibition of nitric oxide synthesis plays a role in the mechanism of action of ketamine. This randomized, placebo-controlled study investigated whether co-administration of sodium nitroprusside, a nitric oxide donor, compared to placebo, would attenuate the antidepressant and dissociative effects of ketamine. Sixteen ketamine responders were randomized to a double-blind infusion of ketamine co-administered with placebo or sodium nitroprusside. Our findings show no difference between the two conditions suggesting that the nitric oxide pathway may not play a primary role in ketamine's antidepressant or dissociative effects. The study is registered at clinicaltrials.gov (NCT03102736). [ABSTRACT FROM AUTHOR]
- Subjects :
- KETAMINE
ANTIDEPRESSANTS
RANDOMIZED controlled trials
NITRIC oxide
METHYL aspartate receptors
SODIUM nitroferricyanide
RESEARCH
RESEARCH methodology
CELL receptors
EXCITATORY amino acid antagonists
MEDICAL cooperation
EVALUATION research
CELLULAR signal transduction
CARDIOVASCULAR agents
COMPARATIVE studies
MENTAL depression
BLIND experiment
Subjects
Details
- Language :
- English
- ISSN :
- 02698811
- Volume :
- 35
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 148516252
- Full Text :
- https://doi.org/10.1177/0269881120985147