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The effectiveness of intravenous ketamine in adults with treatment-resistant major depressive disorder and bipolar disorder presenting with prominent anxiety: Results from the Canadian Rapid Treatment Center of Excellence.
- Source :
- Journal of Psychopharmacology; Feb2021, Vol. 35 Issue 2, p128-136, 9p
- Publication Year :
- 2021
-
Abstract
- Background: Individuals meeting criteria for treatment-resistant depression (TRD) are differentially affected by high levels of anxiety symptoms. Aims: There is a need to identify the efficacy of novel rapid-onset treatments in adults with mood disorders and comorbid anxious-distress. Methods: This study included patients with treatment-resistant major depressive disorder (MDD) or bipolar disorder (BD) who were receiving intravenous (IV) ketamine treatment at a community-based clinic.Anxious-distress was proxied using items from the Quick Inventory of Depressive Symptomatology–Self Report 16-item (QIDS-SR<subscript>16</subscript>) and Generalized Anxiety Disorder 7-item (GAD7) scales. The difference in QIDS-SR<subscript>16</subscript> total score, QIDS-SR<subscript>16</subscript> suicidal ideation (SI) item and GAD7 score were analyzed between groups. Results: A total of 209 adults with MDD (n = 177) and BD (n = 26) were included in this analysis. From this sample, 94 patients (mean = 45 ± 13.9 years) met the criteria for anxious-distress. Individuals meeting the criteria for anxious-distress exhibited a significantly greater reduction in QIDS-SR<subscript>16</subscript> total score following four infusions (p = 0.02) when compared with patients not meeting the anxious-distress criteria. Both anxious-distressed and low-anxiety patients exhibited a significant reduction in SI (p < 0.0001) following four infusions.Finally, there was a significantly greater reduction in anxiety symptoms in the anxious-distress group compared with the non–anxious distress group following three (p = 0.02) and four infusions (p < 0.001). Conclusion: Patients with TRD and prominent anxiety receiving IV ketamine exhibited a significant reduction in depressive, SI and anxiety symptoms. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02698811
- Volume :
- 35
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 148516248
- Full Text :
- https://doi.org/10.1177/0269881120954048