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The CKiD study: overview and summary of findings related to kidney disease progression.

Authors :
Atkinson, Meredith A.
Ng, Derek K.
Warady, Bradley A.
Furth, Susan L.
Flynn, Joseph T.
Source :
Pediatric Nephrology; 2021, Vol. 36 Issue 3, p527-538, 12p, 4 Charts
Publication Year :
2021

Abstract

The Chronic Kidney Disease in Children (CKiD) cohort study is a North American (USA and Canada) multicenter, prospective study of children with chronic kidney disease (CKD). The original aims of the study were (1) to identify novel risk factors for CKD progression; (2) to measure the impact of kidney function decline on growth, cognition, and behavior; and (3) to characterize the evolution of cardiovascular disease risk factors. CKiD has developed into a national and international resource for the investigation of a variety of factors related to CKD in children. This review highlights notable findings in the area of CKD progression and outlines ongoing opportunities to enhance understanding of CKD progression in children. CKiD's contributions to the clinical care of children with CKD include updated and more accurate glomerular filtration rate estimating equations for children and young adults, and resources designed to help estimate the CKD progression timeline. In addition, results from CKiD have strengthened the evidence that treatment of hypertension and proteinuria should continue as a primary strategy for slowing the rate of disease progression in children. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0931041X
Volume :
36
Issue :
3
Database :
Complementary Index
Journal :
Pediatric Nephrology
Publication Type :
Academic Journal
Accession number :
148426651
Full Text :
https://doi.org/10.1007/s00467-019-04458-6