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Effects of neoadjuvant chemotherapy on the contralateral non-tumor-bearing breast assessed by diffuse optical tomography.
- Source :
- Breast Cancer Research; 1/31/2021, Vol. 23 Issue 1, p1-9, 9p
- Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>The purpose of this study is to evaluate whether the changes in optically derived parameters acquired with a diffuse optical tomography breast imager system (DOTBIS) in the contralateral non-tumor-bearing breast in patients administered neoadjuvant chemotherapy (NAC) for breast cancer are associated with pathologic complete response (pCR).<bold>Methods: </bold>In this retrospective evaluation of 105 patients with stage II-III breast cancer, oxy-hemoglobin (ctO2Hb) from the contralateral non-tumor-bearing breast was collected and analyzed at different time points during NAC. The earliest monitoring imaging time point was after 2-3 weeks receiving taxane. Longitudinal data were analyzed using linear mixed-effects modeling to evaluate the contralateral breast ctO2Hb changes across chemotherapy when corrected for pCR status, age, and BMI.<bold>Results: </bold>Patients who achieved pCR to NAC had an overall decrease of 3.88 μM for ctO2Hb (95% CI, 1.39 to 6.37 μM), p = .004, after 2-3 weeks. On the other hand, non-pCR subjects had a non-significant mean reduction of 0.14 μM (95% CI, - 1.30 to 1.58 μM), p > .05. Mixed-effect model results indicated a statistically significant negative relationship of ctO2Hb levels with BMI and age.<bold>Conclusions: </bold>This study demonstrates that the contralateral normal breast tissue assessed by DOTBIS is modifiable after NAC, with changes associated with pCR after only 2-3 weeks of chemotherapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- OPTICAL tomography
NEOADJUVANT chemotherapy
BREAST
BREAST cancer
Subjects
Details
- Language :
- English
- ISSN :
- 14655411
- Volume :
- 23
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Breast Cancer Research
- Publication Type :
- Academic Journal
- Accession number :
- 148404636
- Full Text :
- https://doi.org/10.1186/s13058-021-01396-w