Editorial: Control of Regulatory T Cell Stability, Plasticity, and Function in Health and Disease.

Keywords: regulatory T cell (T reg); plasticity; autoimmunity; cancer; metabolism EN regulatory T cell (T reg) plasticity autoimmunity cancer metabolism N.PAG N.PAG 3 02/02/21 20210127 NES 210127 Regulatory T cells (CD4 SP + sp CD25 SP high sp CD127 SP - sp FOXP3 SP + sp , Tregs) play a fundamental role in maintaining immune homeostasis by modulating the immune response against self-antigens, allergens, pathogens, and tumors. Stable and long-term expression of Foxp3 in Tregs is essential for Treg function and is partly controlled by the demethylation of Treg-specific epigenetic signature genes, including Foxp3 ([2]). Using a conditional Treg-specific Tbet KO, they observe that Tbet expression in Tregs is required for the development of colitis, and mice with Tbet KO Tregs develop milder colitis. [Extracted from the article]