Diterpenoids from the Seeds of Euphorbia lathyris and their in Vitro Anti-HIV Activity.

We have systematically investigated the chemical constituents of E. lathyris from Hebei Province. Consequently, a new ingenane-type diterpenoid (1) was isolated, together with 17 known diterpenoids (2–18). The structures of these compounds were established by NMR spectra and comparison with the literature. The anti-HIV activity of ethanol extracts of the seeds of Euphorbia lathyris from different origins was evaluated. The results showed that all the ethanol extracts exhibited significant anti-HIV activity. The anti-HIV activity of the 18 compounds was determined, but all of the compounds were inactive against HIV viral replication. [ABSTRACT FROM AUTHOR]