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Case Report: B Lymphocyte Disorders Under COVID-19 Inflammatory Pressure.
- Source :
- Frontiers in Oncology; 1/25/2021, Vol. 11, pN.PAG-N.PAG, 8p
- Publication Year :
- 2021
-
Abstract
- Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects humans through the angiotensin converting enzyme-2 (ACE-2) receptor expressed on many cells, including lymphocytes. In Covid-19 patients IL-6 is overexpressed, and hyperactivated plasmacytoid lymphocytes are detected in peripheral blood film. We hypothesize that, due to the unpredictable interaction between the new virus and the B cell lineage of infected patients, a cascade of out of control events can ensue, capable of determining unexpected pathologic disorders involving such lineage. Here we report two cases of autoimmune hemolytic anemia (AIHA) and two cases of B-cell hematological malignancies developed or reactivated during acute SARS-CoV-2 infection. The temporal relationship of the events may suggest a potential causal relationship between SARS-CoV-2 infection and the hematopoietic disorders. We suggest that special attention should be paid to COVID-19 patients with underlining B cell lineage disorders. [ABSTRACT FROM AUTHOR]
- Subjects :
- SARS-CoV-2
B cells
COVID-19
AUTOIMMUNE hemolytic anemia
Subjects
Details
- Language :
- English
- ISSN :
- 2234943X
- Volume :
- 11
- Database :
- Complementary Index
- Journal :
- Frontiers in Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 148342446
- Full Text :
- https://doi.org/10.3389/fonc.2020.582901