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Efficacy of endovascular embolization of arterial pseudoaneurysms in pancreatitis: A systematic review and meta-analysis.
Efficacy of endovascular embolization of arterial pseudoaneurysms in pancreatitis: A systematic review and meta-analysis.
- Source :
- Pancreatology (Elsevier Science); Jan2021, Vol. 21 Issue 1, p46-58, 13p
- Publication Year :
- 2021
-
Abstract
- There is a significant variability in the reported outcomes following endovascular embolization of arterial pseudoaneurysms in pancreatitis. The objective of this systematic review and meta-analysis is to evaluate the efficacy of endovascular embolization of pancreatitis-related pseudoaneurysms. Searches of MEDLINE, EMBASE, and SCOPUS databases were performed through July 1, 2019 in accordance with PRISMA guidelines. All studies with ≥10 patients reporting technical success, clinical success, complications, and mortality were included. Generalized linear mixed method with random effects model was used for assessing pooled incidence rates and corresponding 95% confidence intervals (CIs). A total of 29 studies (n = 840 with 638 pseudoaneurysms) were included. The pooled incidence rates of pseudoaneurysms in acute and chronic pancreatitis were 0.05% and 0.03%, respectively (odds ratio, 0.91, 95% CI-0.24–3.43). The most common site of pseudoaneurysm was splenic artery (37.7%). The most common embolization agent was coil (n = 415). The follow up period was 54.7 months (range, 21 days to 40.5 months). Pooled technical success rate was 97% (95% CI-92-99%, I<superscript>2</superscript> 83%). Clinical success rates at ≤3 months, 3–12 months, and >12 months were 82% (95% CI-70-90%, I<superscript>2</superscript> 42%), 86% (95% CI-75-92%, I<superscript>2</superscript> 44%), and 88% (95% CI-83-91%, I<superscript>2</superscript> 0%), respectively. There was no significant difference in the technical or clinical success between acute and chronic pancreatitis on subgroup analysis. Mortality was lower in chronic pancreatitis (OR 4.27 (95% CI 1.35–13.53, I<superscript>2</superscript> 0%)). Splenic infarction was the most common complication (n = 47). Endovascular embolization is associated with a high technical and clinical success. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14243903
- Volume :
- 21
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Pancreatology (Elsevier Science)
- Publication Type :
- Academic Journal
- Accession number :
- 148166361
- Full Text :
- https://doi.org/10.1016/j.pan.2020.11.017