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Association of Interactions Between Mammographic Density Phenotypes and Established Risk Factors With Breast Cancer Risk, by Tumor Subtype and Menopausal Status.

Authors :
Chen, Hongjie
Yaghjyan, Lusine
Li, Christopher
Peters, Ulrike
Rosner, Bernard
Lindström, Sara
Tamimi, Rulla M
Source :
American Journal of Epidemiology; Jan2021, Vol. 190 Issue 1, p44-58, 15p
Publication Year :
2021

Abstract

Previous studies suggest that the association between mammographic density (MD) and breast cancer risk might be modified by other breast cancer risk factors. In this study, we assessed multiplicative interactions between MD measures and established risk factors on the risk of invasive breast cancer overall and according to menopausal and estrogen receptor status. We used data on 2,137 cases and 4,346 controls from a nested case-control study within the Nurses' Health Study (1976–2004) and Nurses' Health Study II (1989–2007), whose data on percent mammographic density (PMD) and absolute area of dense tissue and nondense tissue (NDA) were available. No interaction remained statistically significant after adjusting for number of comparisons. For breast cancer overall, we observed nominally significant interactions (P  < 0.05) between nulliparity and PMD/NDA, age at menarche and area of dense tissue, and body mass index and NDA. Individual nominally significant interactions across MD measures and risk factors were also observed in analyses stratified by either menopausal or estrogen receptor status. Our findings help provide further insights into potential mechanisms underlying the association between MD and breast cancer. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00029262
Volume :
190
Issue :
1
Database :
Complementary Index
Journal :
American Journal of Epidemiology
Publication Type :
Academic Journal
Accession number :
148072189
Full Text :
https://doi.org/10.1093/aje/kwaa131