RNA‐seq–based profiling of extracellular vesicles in plasma reveals a potential role of miR‐122‐5p in asthma.

RNA-seq-based profiling of extracellular vesicles in plasma reveals a potential role of miR-122-5p in asthma Keywords: asthma; biomarkers; endotypes; microRNA; precision medicine EN asthma biomarkers endotypes microRNA precision medicine 366 371 6 01/09/21 20210101 NES 210101 To the Editor, Asthma is a heterogeneous disease encompassing several distinct sub-phenotypes with different etiologies and treatment responses,1 but we are lacking markers to differentiate patient subgroups. Combined with the IPA-predicted role in lymphocyte differentiation and function, it is intriguing to speculate that this miRNA can sub-differentiate different forms of asthma, such as neutrophilic from eosinophilic asthma. [Extracted from the article]