Transcriptome analysis reveals two distinct endotypes and putative immune pathways in tonsils from children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome.

Keywords: endotype; innate immune response; PFAPA syndrome; phenotype; tonsil EN endotype innate immune response PFAPA syndrome phenotype tonsil 359 363 5 01/09/21 20210101 NES 210101 To the Editor Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome (PFAPA) is one of the most common periodic fevers in children. C, Correlations between mRNA expression levels of monocyte/macrophage cell markers (CD14 and CD68) and mRNA expression levels of innate immunity-related genes (TLR2, 4, 8, and NLRC4) in Endotype 1 are shown. Microbes of the tonsils in PFAPA (Periodic Fever, Aphtous stomatitis, Pharyngitis and Adenitis) syndrome - a possible trigger of febrile episodes. [Extracted from the article]