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The ototoxic potential of cobalt from metal-on-metal hip implants: a pilot study on the patient-reported auditory, vestibular, and general neurological outcome.
- Source :
- International Journal of Audiology; Jan2021, Vol. 60 Issue 1, p44-53, 10p, 5 Charts
- Publication Year :
- 2021
-
Abstract
- This study aimed to systematically investigate the ototoxic potential of cobalt in patients with a metal-on-metal (MoM) hip implant, using objective auditory and vestibular assessments and a questionnaire. The results of the objective evaluation were published previously, whereas the current study focused on the questionnaire outcome and its relationship to the blood cobalt level. Design and study sample: Twenty patients (33–65 years) with a primary MoM hip implant and 20 non-implanted control subjects, matched for age, gender, and noise exposure, received a questionnaire to evaluate the presence of several hearing and balance symptoms (part 1) and general neurological issues (part 2). Concerning part 1, the proportion of auditory-related symptoms in general (p = 0.022) and tinnitus (p = 0.047) was significantly higher in the MoM patient group, whereas no group difference was found for hyperacusis, increased listening effort, and decreased speech understanding. Concerning part 2, no significant group differences were detected. Within the MoM patient group, the questionnaire outcome was not significantly different between the low-exposure and high-exposure subgroups according to the blood Co level. In line with our previous study, these results potentially imply Co-induced impairment to the auditory system, despite the lack of a clear dose–response relationship. [ABSTRACT FROM AUTHOR]
- Subjects :
- ARTIFICIAL joints
COBALT
DOSE-response relationship in biochemistry
FISHER exact test
HEALTH status indicators
HEARING
NERVOUS system
NEUROTOXICOLOGY
HEALTH outcome assessment
STATISTICAL hypothesis testing
SYNDROMES
TINNITUS
TOTAL hip replacement
COMORBIDITY
PILOT projects
OTOTOXICITY
RELATIVE medical risk
DATA analysis software
DESCRIPTIVE statistics
DISEASE risk factors
EVALUATION
SYMPTOMS
Subjects
Details
- Language :
- English
- ISSN :
- 14992027
- Volume :
- 60
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- International Journal of Audiology
- Publication Type :
- Academic Journal
- Accession number :
- 147926923
- Full Text :
- https://doi.org/10.1080/14992027.2020.1789922