Detectable anti-proteinase-3 antibodies precede clinical manifestations in a case of anti-neutrophil cytoplasmic antibody-associated vasculitis.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are devastating clinical syndromes characterized by small vessel vasculitis occasioning multiorgan dysfunction, such as renal and pulmonic involvement, and ANCAs. Anti-neutrophil cytoplasmic antibody (ANCA) levels directed against proteinase-3 and myeloperoxidase are helpful in predicting disease relapse in ANCA-associated small-vessel vasculitis. [Extracted from the article]