IMMUNOHISTOCHEMICAL EXPRESSION OF ANNEXIN A5 PROTEINS IN PROSTATIC ADENOCARCINOMA IN CORRELATION WITH SOME CLINICO-PATHOLOGICAL PARAMETERS IN A SAMPLE OF IRAQI PATIENTS.

Prostate cancer is the second most frequent cancer diagnosis made in men and the fifth leading cause of death worldwide. Prostate cancer may be asymptomatic at the early stage and often has an indolent course and may require minimal or even no treatment. More advanced stage of the disease may present with urinary retention and back pain, as axis skeleton is the most common site of bony metastatic disease. The aim of this study is to examines the expressin of annexin A5 proteins in prostatic adenocarcinoma in correlation with some clinico-pathological parameters in a sample of Iraqi patients. A retrospective cross-sectional study included 30 patients diagnosed with prostatic adenocarcinoma and other 30 patients diagnosed with benign prostatic hyperplasia BPH in Baghdad, Iraq from Oct. 2018 - Oct. 2019 were evaluated. Of the 60 patients enrolled in this study; 65% of patients showed positive Annexin A5 expression whie 35% was ngative. Although, there's no statistical significant association in Annexin A5 expression between benign and malignant lesions but in prostatic cancer patients we noticed that threre's significant association between perineural invasion and Annexin A5 expression. Annexin A5 expression can be a potential marker for tumor aggressiveness and invasion that make it candidate for more aggressive management. [ABSTRACT FROM AUTHOR]