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Infective endocarditis at a tertiary care hospital in South Korea.
- Source :
- Heart; 1/15/2021, Vol. 107 Issue 2, p135-141, 7p
- Publication Year :
- 2021
-
Abstract
- <bold>Objective: </bold>The treatment of infective endocarditis (IE) has become more complex with the current myriad healthcare-associated factors and the regional differences in causative organisms. We aimed to investigate the overall trends, microbiological features, and outcomes of IE in South Korea.<bold>Methods: </bold>A 12-year retrospective cohort study was performed. Poisson regression was used to estimate the time trends of IE incidence and mortality rate. Risk factors for in-hospital mortality were identified with multivariable logistic regression, and model comparison was performed to evaluate the predictive performance of notable risk factors. Kaplan-Meier survival analysis and Cox regression were performed to assess long-term prognosis.<bold>Results: </bold>We included 419 patients with IE, the incidence of which showed an increasing trend (relative risk 1.06, p=0.005), whereas mortality demonstrated a decreasing trend (incidence rate ratio 0.93, p=0.020). The in-hospital mortality rate was 14.6%. On multivariable logistic regression analysis, aortic valve endocarditis (OR 3.18, p=0.001), IE caused by Staphylococcus aureus (OR 2.32, p=0.026), neurological complications (OR 1.98, p=0.031), high Sequential Organ Failure Assessment score (OR 1.22, p=0.023) and high Charlson Comorbidity Index (OR 1.11, p=0.019) were predictors of in-hospital mortality. Surgical intervention for IE was a protective factor against in-hospital mortality (OR 0.25, p<0.001) and was associated with improved long-term prognosis compared with medical treatment only (p<0.001).<bold>Conclusions: </bold>The incidence of IE is increasing in South Korea. Although the mortality rate has slightly decreased, it remains high. Surgery has a protective effect with respect to both in-hospital mortality and long-term prognosis in patients with IE. [ABSTRACT FROM AUTHOR]
- Subjects :
- INFECTIVE endocarditis
CARDIAC pacemakers
ANTIBIOTIC prophylaxis
DISEASE risk factors
HOSPITAL care
TERTIARY care
APACHE (Disease classification system)
RESEARCH
SPECIALTY hospitals
RESEARCH methodology
DISEASE incidence
RETROSPECTIVE studies
MEDICAL cooperation
EVALUATION research
TREATMENT effectiveness
COMPARATIVE studies
QUESTIONNAIRES
LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 13556037
- Volume :
- 107
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Heart
- Publication Type :
- Academic Journal
- Accession number :
- 147760555
- Full Text :
- https://doi.org/10.1136/heartjnl-2020-317265