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Looking back at multidrug resistance (MDR) research and ten mistakes to be avoided when writing about ABC transporters in MDR.

Authors :
Borst, Piet
Source :
FEBS Letters; Dec2020, Vol. 594 Issue 23, p4001-4011, 11p
Publication Year :
2020

Abstract

This paper presents a personal, selective, and sometimes critical retrospective of the history of ABC transporters in multidrug resistance (MDR) of cancer cells, overrepresenting discoveries of some early pioneers, long forgotten, and highlights of research in Amsterdam, mainly focussing on discoveries made with disruptions of ABC genes in mice (KO mice) and on the role of ABC transporters in causing drug resistance in a mouse model of mammary cancer. The history is complemented by a list of erroneous concepts often found in papers and grant applications submitted anno 2020. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00145793
Volume :
594
Issue :
23
Database :
Complementary Index
Journal :
FEBS Letters
Publication Type :
Academic Journal
Accession number :
147676155
Full Text :
https://doi.org/10.1002/1873-3468.13972