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Effect of emicizumab on thrombin generation: A case report of breakthrough bleeding during emicizumab treatment.

Effect of emicizumab on thrombin generation: A case report of breakthrough bleeding during emicizumab treatment.

Authors :
Valke, Lars L. F. G.
Beckers, Erik A. M.
Blijlevens, Nicole M. A.
Heerde, Waander L.
Schols, Saskia E. M.
Source :
Haemophilia; Nov2020, Vol. 26 Issue 6, pe327-e330, 4p, 1 Color Photograph, 1 Chart
Publication Year :
2020

Abstract

Dear Editor, Present-day care treatment for patients with severe haemophilia A (HA) consists of factor VIII (FVIII) replacement as prophylaxis or on demand in case of bleeding. Reconsidering the results of the NHA, treatment with rFVIIa in this patient would have led to a more pronounced thrombin generation in the acute setting of haemorrhage, thereby providing probably better haemostasis. In the pivotal report of this new agent, TGA is used to monitor the pharmacodynamic effect of this drug.5 In this patient, FVIII replacement therapy was given for breakthrough bleeding by the emergency physician as this was mentioned in his treatment plan. 2014; 20 (1):e 7 - 14. 10 Dargaud Y, Lienhart A, Janbain M, Le Quellec S, Enjolras N, Negrier C. Use of thrombin generation assay to personalize treatment of breakthrough bleeds in a patient with hemophilia and inhibitors receiving prophylaxis with emicizumab. [Extracted from the article]

Details

Language :
English
ISSN :
13518216
Volume :
26
Issue :
6
Database :
Complementary Index
Journal :
Haemophilia
Publication Type :
Academic Journal
Accession number :
147674464
Full Text :
https://doi.org/10.1111/hae.14085