Back to Search
Start Over
Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis.
- Source :
- Acta Dermato-Venereologica; Dec2020, Vol. 100 Issue 12, p1-8, 8p
- Publication Year :
- 2020
-
Abstract
- Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and immune cell infiltration into the skin, often accompanied by itch. Histamine, acting via histamine 1-4 receptors, is known to modulate immune responses in the skin and to induce itch. The aim of this study was to test the role of histamine 2 receptors and histamine 4 receptors in the imiquimod-induced psoriasis-like skin inflammation model. BALB/c mice were treated intraperitoneally with amthamine (histamine 2 receptor agonist), JNJ-39758979 (histamine 4 receptor antagonist), a combination of both, or vehicle twice daily in a preventive manner. Imiquimod was applied once daily onto the back skin for 10 consecutive days. Stimulation of histamine 2 receptors and blockade of histamine 4 receptors ameliorated imiquimod-induced skin inflammation. The combination of amthamine and JNJ-39758979 reduced skin inflammation even more, diminished epidermal hyperproliferation, and inhibited spontaneous scratching behaviour. A combination of histamine 2 receptor agonist and histamine 4 receptor antagonists could represent a new strategy for the treatment of psoriasis. [ABSTRACT FROM AUTHOR]
- Subjects :
- HISTAMINE receptors
ANTIHISTAMINES
PSORIASIS
SKIN inflammation
IMIQUIMOD
Subjects
Details
- Language :
- English
- ISSN :
- 00015555
- Volume :
- 100
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Acta Dermato-Venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 147591584
- Full Text :
- https://doi.org/10.2340/00015555-3674