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The 23S Ribosomal RNA From Pyrococcus furiosus Is Circularly Permuted.
- Source :
- Frontiers in Microbiology; 12/10/2020, Vol. 11, pN.PAG-N.PAG, 11p
- Publication Year :
- 2020
-
Abstract
- Synthesis and assembly of ribosomal components are fundamental cellular processes and generally well-conserved within the main groups of organisms. Yet, provocative variations to the general schemes exist. We have discovered an unusual processing pathway of pre-rRNA in extreme thermophilic archaea exemplified by Pyrococcus furiosus. The large subunit (LSU) rRNA is produced as a circularly permuted form through circularization followed by excision of Helix 98. As a consequence, the terminal domain VII that comprise the binding site for the signal recognition particle is appended to the 5´ end of the LSU rRNA that instead terminates in Domain VI carrying the Sarcin-Ricin Loop, the primary interaction site with the translational GTPases. To our knowledge, this is the first example of a true post-transcriptional circular permutation of a main functional molecule and the first example of rRNA fragmentation in archaea. [ABSTRACT FROM AUTHOR]
- Subjects :
- PYROCOCCUS furiosus
BINDING sites
ARCHAEBACTERIA
PERMUTATIONS
RIBOSOMAL RNA
Subjects
Details
- Language :
- English
- ISSN :
- 1664302X
- Volume :
- 11
- Database :
- Complementary Index
- Journal :
- Frontiers in Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 147549710
- Full Text :
- https://doi.org/10.3389/fmicb.2020.582022