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Maternal folate, one‐carbon metabolism and pregnancy outcomes.
- Source :
- Maternal & Child Nutrition; Jan2021, Vol. 17 Issue 1, p1-17, 17p
- Publication Year :
- 2021
-
Abstract
- Single nucleotide polymorphisms and pre‐ and peri‐conception folic acid (FA) supplementation and dietary data were used to identify one‐carbon metabolic factors associated with pregnancy outcomes in 3196 nulliparous women. In 325 participants, we also measured circulating folate, vitamin B12 and homocysteine. Pregnancy outcomes included preeclampsia (PE), gestational hypertension (GHT), small for gestational age (SGA), spontaneous preterm birth (sPTB) and gestational diabetes mellitus (GDM). Study findings show that maternal genotype MTHFR A1298C(CC) was associated with increased risk for PE, whereas TCN2 C766G(GG) had a reduced risk for sPTB. Paternal MTHFR A1298C(CC) and MTHFD1 G1958A(AA) genotypes were associated with reduced risk for sPTB, whereas MTHFR C677T(CT) genotype had an increased risk for GHT. FA supplementation was associated with higher serum folate and vitamin B12 concentrations, reduced uterine artery resistance index and increased birth weight. Women who supplemented with <800 μg daily FA at 15‐week gestation had a higher incidence of PE (10.3%) compared with women who did not supplement (6.1%) or who supplemented with ≥800 μg (5.4%) (P <.0001). Higher serum folate levels were found in women who later developed GDM compared with women with uncomplicated pregnancies (Mean ± SD: 37.6 ± 8 nmol L−1 vs. 31.9 ± 11.2, P =.007). Fast food consumption was associated with increased risk for developing GDM, whereas low consumption of green leafy vegetables and fruit were independent risk factors for SGA and GDM and sPTB and SGA, respectively. In conclusion, maternal and paternal genotypes, together with maternal circulating folate and homocysteine concentrations, and pre‐ and early‐pregnancy dietary factors, are independent risk factors for pregnancy complications. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of folic acid
RISK factors of preeclampsia
CARBON metabolism
BIRTH size
BIRTH weight
CONFIDENCE intervals
GESTATIONAL diabetes
DIET
DIETARY supplements
FATHERS
FOLIC acid
FOOD habits
HYPERTENSION in pregnancy
PREMATURE infants
INGESTION
INTERVIEWING
PREGNANCY complications
PREGNANT women
RESEARCH funding
RISK assessment
VITAMIN B12
HOMOCYSTEINE
MULTIPLE regression analysis
SECONDARY analysis
DATA analysis software
SINGLE nucleotide polymorphisms
DESCRIPTIVE statistics
ODDS ratio
GENOTYPES
PREGNANCY outcomes
DISEASE risk factors
PREGNANCY
Subjects
Details
- Language :
- English
- ISSN :
- 17408695
- Volume :
- 17
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Maternal & Child Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 147546975
- Full Text :
- https://doi.org/10.1111/mcn.13064